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Evolutionary model of PUF network rewiring. Colored boxes represent orthologous sets of mRNA targets. Solid arrows indicate PUF binding of the denoted binding element enriched in the target mRNA UTRs; dashed arrows represent weak binding or secondary modes of regulation (Discussion for details). Dashed colored boxes represent the acquisition or loss of transcripts from the denoted regulon. Mt, mitochondrial; Ribo, ribosomal.
