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. 2017 Feb;187(2):418–430. doi: 10.1016/j.ajpath.2016.10.022

Figure 3.

Figure 3

A: Representative 4-hydroxynonenal (4-Hne) adduct staining in livers of Wt, Gsta4−/−, Ppara−/−, and Ppara−/−/gsta4−/− double-knockout (dKO) mice fed 70% polyunsaturated fat (HF) diets. B: Ratio of zone 1/zone 3 staining. Statistical analysis was determined by two-way analysis of variance, followed by Student-Newman-Keuls post hoc analysis. Data are expressed as means ± SEM (B). n = 6 to 8 per group (B). ∗P < 0.05 for chow (C) versus 70% HF diet (within each genotype); ‡P < 0.05, ‡‡P < 0.01 (between genotypes for 70% HF diet).