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. 2017 Feb;187(2):352–365. doi: 10.1016/j.ajpath.2016.10.009

Figure 5.

Figure 5

AMG487, antagonist of CXCR3, preserves retinal function and prevents retinal ganglion cell loss after traumatic optic neuropathy (TON). Wild-type mice were i.p. injected with vehicle (Veh) or AMG487 (20 mg/kg) at 1 and 12 hours before TON procedure and continuously injected twice a day for 7 days after TON. A: Body weights of vehicle- and AMG487-treated TON mice. B: Graph represents average amplitudes of positive scotopic threshold response (pSTR) over a range of stimulus strengths. C: Representative pSTR patterns for stimuli of −4.0 log cd-second/m2. D: Retinas were collected from noninjured mice [control (Con)] and TON mice treated with vehicle or AMG487. Representative images of retinal flat mounts labeled with Tuj1 antibody (green) were shown. Bar graph represents the number of Tuj1-positive cells per field. n = 5 to 7 mice (B); n = 8 to 9 mice (D). ∗P < 0.05 versus noninjured control mice (Con); †P < 0.05 versus vehicle-treated TON mice; ‡‡‡P < 0.001. Scale bars = 50 μm.