Figure 2.

Fever onset was accompanied by increases in mean arterial blood pressure and respiratory rate, but not heart rate. A–D: Telemetry was used to measure changes in core body temperature (temp; A), mean arterial pressure (MAP; B), respiratory rate (C), and heart rate (D). The data from the representative rat shown herein (exposed to 853 CFUs SCHU S4) demonstrate the onset of fever at 61 hours after exposure, as denoted by the dashed vertical lines. Note the lack of increase in heart rate at the onset of fever. E and F: Expanded graphs showing core body temperature from the same rat over a 90-hour period before exposure (E) and a 90-hour period starting at the onset of fever (F). Note the diurnal variation in core body temperature before exposure, and the lack of diurnal variation after the onset of fever. Telemetry data for other rats were similar, with only minor differences in the time of fever onset. bpm, beats per minute.