Table 1.
Overview of Dose Prediction Models Tested
| Genetic Model
|
|||||
|---|---|---|---|---|---|
| Clinical Only | Limited Genetic | Expanded Genetic | Combined SNP | Haplotype | |
| Clinical Vars. (All) | Age (in decades); Body surface area; Smoking status; Amiodarone; Enzyme inducer | ||||
| Race Adj. (one of:) | 1) Unadjusted 2) EMR Race 3) %African Ancestry 4) White Only 5) Black Only |
||||
| Genetic Variables | - | VKORC1-1639 | VKORC1-1639 | VKORC1-1639 | VKORC1-1639 |
| CYP2C9*2 | CYP2C9*2 | CYP2C9*2 | rs2359612 | ||
| CYP2C9*3 | CYP2C9*3 | CYP2C9*3 | rs2884737 | ||
| CYP2C9*5 | rs7200749 | rs7200749 | |||
| CYP2C9*6 | rs9934438 | rs8050894 | |||
| CYP2C9*8 | rs17886199 | rs9934438 | |||
| CYP2C9*11 | rs10871454 | rs17886199 | |||
| rs2359612 | rs2108622 | rs10871454 | |||
| rs2884737 | rs11676382 | rs2108622 | |||
| rs7200749 | rs12714145 | rs11676382 | |||
| rs8050894 | rs339097 | rs12714145 | |||
| rs9934438 | rs12777823 | rs339097 | |||
| rs17886199 | VKORC1 Other1 | rs12777823 | |||
| rs10871454 | CYP2C9 Other2 | CYP2C9*1/*2 | |||
| rs2108622 | CYP2C9*1/*3 | ||||
| rs11676382 | CYP2C9*2/*2 | ||||
| rs12714145 | CYP2C9*2/*3 | ||||
| rs339097 | CYP2C9*3/*3 | ||||
| rs12777823 | CYP2C9 Other Het.3 | ||||
| CYP2C9 Other Hom.4 | |||||
1
If individual carries one or more minor allele at rs2359612 or rs2884737 or rs61162043 or rs8050894 then called 1, else 0;
2
If individual carries one or more minor allele at CYP2C9 *5/*6/*8 or *11 then call 1, else 0;
3
CYP2C9 *1/*11, *1/*5, *1/*6, *1/*8);
4
CYP2C9 *3/*8, *5/*8, *5/*11, *8/*8, *8/*11