Table 4.

Genotyping Quality Control and Minor Allele Frequencies

Gene	SNP	Minor Allele	Call Ratea	Minor Allele Frequency (%)
				Combined (n=2181)	Whites (n=1928)	Blacks (n=253)
VKORC1	rs9923231	T	99.79b	35.1	38.3	10.5
VKORC1	rs2359612	A	100	36.4	38.5	20.8
VKORC1	rs2884737	C	99.96	23.3	25.3	3.8
VKORC1	rs61162043	A	93.82	37.2	35.8	49.6
VKORC1	rs7200749	A	99.96	2.6	0.3	20.2
VKORC1	rs8050894	G	99.92	37.3	38.8	26.5
VKORC1	rs9934438	A	99.96	35.1	38.4	10.5
VKORC1	rs17886199	G	100	0.5	0	4.2
STX4	rs10871454	T	99.96	35.3	38.5	10.9
CYP2C9*2	rs1799853	T	99.79b	13.5	14.9	2.4
CYP2C9*3	rs1057910	C	99.95b	6.1	6.7	2.0
CYP2C9*5	rs28371686	G	100	0.2	0.05	1.6
CYP2C9*6	rs9332131	del	99.79	0.2	0	1.4
CYP2C9*8	rs7900194	A	100	0.9	0.03	7.3
CYP2C9*11	rs28371685	T	99.96	0.4	0.3	1.4
CYP4F2	rs2108622	T	100	28.2	30.4	11.3
GGCX	rs11676382	G	99.96	8.8	9.7	2.6
GGCX	rs12714145	T	100	42.1	41.6	45.8
CALU	rs339097	G	99.83	1.6	0.2	12.3
CYP2C-cluster	rs12777823	A	99.92	16.1	14.6	28.1

^aCall rates for completed genotyped population – not the final study population (as valid genotypes required for all but rs61162043);

^bCall rate for Taqman group only. ADME QC according to typical procedures.