Table 6.
Performance of Predictive Dosing Algorithms
| Algorithm | Mean Absolute Error (mg/week) Median (95% Confidence Interval) |
Percent Variation Explained (R2) Median (95% Confidence Interval) |
||||
|---|---|---|---|---|---|---|
| Combined | Whites | Blacks | Combined | Whites | Blacks | |
| Existing Algorithms | ||||||
|
| ||||||
| Fixed 35 mg/week | 13.5 | 13.2 | 16.1 | −2.3 | −1.1 | −23.7 |
|
| ||||||
| US FDA Table mid-range | 12.0 | 11.7 | 14.7 | 17.5 | 18.3 | 1.1 |
|
| ||||||
| IWPC | 9.5 | 9.0 | 13.4 | 42.7 | 45.2 | 20 |
|
| ||||||
| Ramirez et. al. | 9.2 | 8.8 | 12.9 | 47.5 | 49.5 | 28.7 |
|
| ||||||
| Hernandez et. al. | 10.4 | 9.9 | 14.2 | 37.3 | 39.4 | 17.2 |
|
| ||||||
| New Models | ||||||
|
| ||||||
| Clinical | ||||||
|
| ||||||
| Unadjusted | 12.0 (11.9–12.0) | 11.7 (11.7–11.8) | 14.0 (13.8–14.2) | 20.3 (19.9–20.5) | 19.6 (19.0–19.9) | 12.3 (9.9–14.9) |
|
| ||||||
| Race Adjusted | 11.9 (11.9–11.9) | 11.7 (11.7–11.7) | 13.6 (13.4–13.8) | 21.5 (21.1–21.6) | 19.8 (19.3–20.0) | 20.8 (18.9–22.1) |
|
| ||||||
| % Ancestry Adjusted | 11.5 (11.5–11.7) | 10.9 (10.8–11.0) | 14.5 (14.3–14.9) | 23.8 (22.9–24.2) | 20.6 (19.3–21.3) | 21.7 (17.9–24.2) |
|
| ||||||
| Race Stratified | - | 11.7 (11.7–11.7) | 13.4 (13.3–13.7) | - | 19.8 (19.4–20.0) | 21.7 (18.0–23.1) |
|
| ||||||
| Limited Genetic | ||||||
|
| ||||||
| Unadjusted | 9.3 (9.2–9.3) | 8.8 (8.8–8.8) | 12.9 (12.8–13.1) | 51.5 (51.2–51.6) | 53.8 (53.4–54.1) | 27.8 (25.4–29.7) |
|
| ||||||
| Race Adjusted | 9.3 (9.2–9.3) | 8.8 (8.8–8.8) | 12.8 (12.7–13.0) | 51.8 (51.5–52.0) | 54.0 (53.6–54.2) | 30.0 (27.8–31.2) |
|
| ||||||
| % Ancestry Adjusted | 9.5 (9.4–9.5) | 8.5 (8.4–8.6) | 13.7 (13.5–14.0) | 49.8 (49.0–50.2) | 52.8 (51.5–53.4) | 32.4 (28.9–34.7) |
|
| ||||||
| Race Stratified | - | 8.8 (8.8–8.8) | 12.7 (12.5–13) | - | 54.0 (53.7–54.2) | 30.9 (27.1–32.5) |
|
| ||||||
| Expanded Genetic | ||||||
|
| ||||||
| Unadjusted | 9.0 (9.0–9.1) | 8.6 (8.6–8.7) | 12.2 (11.9–12.6) | 54.1 (53.6–54.4) | 55.4 (54.9–55.7) | 37.7 (34.0–40.0) |
|
| ||||||
| Race Adjusted | 9.0 (9.0–9.1) | 8.6 (8.6–8.7) | 12.2 (11.9–12.6) | 54.1 (53.5–54.4) | 55.4 (54.9–55.8) | 37.5 (33.5–40.1) |
|
| ||||||
| % Ancestry Adjusted | 9.2 (9.1–9.3) | 8.4 (8.3–8.5) | 12.9 (12.5–13.4) | 52.5 (50.8–53.3) | 54.2 (52.5–55.1) | 39.7 (32.9–43.8) |
|
| ||||||
| Race Stratified | - | 8.6 (8.6–8.7) | 11.9 (11.6–12.4) | - | 55.7 (55.2–55.9) | 39.5 (33.8–42.5) |
|
| ||||||
| Combined SNP | ||||||
|
| ||||||
| Unadjusted | 9.9 (9.9–10.0) | 9.5 (9.5–9.6) | 12.8 (12.6–13.1) | 44.0 (43.5–44.3) | 44.7 (44.2–45.0) | 30.2 (27.2–32.5) |
|
| ||||||
| Race Adjusted | 9.9 (9.9–10.0) | 9.6 (9.5–9.6) | 12.8 (12.6–13.1) | 44.0 (43.5–44.3) | 44.7 (44.2–45.1) | 30.3 (27.0–32.6) |
|
| ||||||
| % Ancestry Adjusted | 10 (9.9–10.1) | 9.2 (9.1–9.3) | 13.6 (13.3–14.0) | 44.4 (43.3–45.0) | 44.8 (43.2–45.8) | 34.2 (29.5–37.9) |
|
| ||||||
| Race Stratified | - | 9.6 (9.5–9.6) | 12.5 (12.2–12.9) | - | 44.9 (44.3–45.1) | 33.9 (29.6–36.4) |
|
| ||||||
| Haplotype | ||||||
|
| ||||||
| Unadjusted | 9.0 (9.0–9.1) | 8.6 (8.6–8.7) | 12.1 (11.8–12.5) | 54.4 (54.0–54.7) | 55.8 (55.3–56.1) | 38.0 (34.5–40.1) |
|
| ||||||
| Race Adjusted | 9.0 (9.0–9.1) | 8.6 (8.6–8.7) | 12.1 (11.9–12.5) | 54.4 (53.9–54.7) | 55.8 (55.3–56.1) | 37.8 (34.3–40.2) |
|
| ||||||
| % Ancestry Adjusted | 9.2 (9.1–9.3) | 8.4 (8.3–8.5) | 12.7 (12.4–13.3) | 53.1 (51.6–53.9) | 54.6 (52.3–55.5) | 41.5 (36.1–44.5) |
|
| ||||||
| Race Stratified | - | 8.6 (8.5–8.6) | 12.0 (11.7–12.5) | - | 56.2 (55.7–56.4) | 39.6 (34.6–42.1) |
|
| ||||||
Bold and shaded cells indicate the best performing algorithm for each population.