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. Author manuscript; available in PMC: 2018 Apr 7.
Published in final edited form as: J Mol Biol. 2017 Feb 27;429(7):999–1008. doi: 10.1016/j.jmb.2017.02.017

Figure 2.

Figure 2

HDXMS analysis of free NFκB (black circles) compared to DNA-bound NFκB (green circles). The interface regions within RelA (salmon) and p50 (cyan) in the NFκB heterodimer that are protected upon DNA binding are shown on a model of the NFκB-DNA complex. Protected regions of RelA are colored red and protected regions of p50 are colored dark blue. Regions of each protein that were not covered in the HDXMS analysis are grey. The deuterium uptake plots are positioned near and arrows point to the corresponding region of the structure.