Table 1.

Gene sets significantly enriched in vocal fold fibroblasts versus oral mucosa fibroblasts.

Gene sets database	Gene sets significantly enriched in VFF versus OMF	FDR q-value	Gene symbols of proteins within core enrichment
Canonical pathways	NABA_MATRISOME	0.0633	P4HA1, PLOD2, FGF2, COL1A2, P4HA2, S100A2, COL6A1, SERPINH1, P3H1, ANXA3, COL12A1, PCOLCE, COL15A1, COL6A2
	NABA_MATRISOME_ASSOCIATED	0.0689	P4HA1, PLOD2, FGF2, P4HA2, S100A2, SERPINH1, P3H1, ANXA
KEGG	KEGG_REGULATION_OF_ACTIN_CYTOSKELETON	0.0440	MYH10, FGF2, ACTN1, ITGA6, MYH9, PPP1R12A, VCL, ACTN4, ARPC3, RDX, ROCK1, CRK, IQGAP1, ROCK2, ACTB, ARPC4
	KEGG_FOCAL_ADHESION	0.0507	COL1A2, ACTN1, ITGA6, COL6A1, PPP1R12A, VCL, FLNB, ACTN4, PARVA, COL6A2, ROCK1, FLNA, CRK, COL6A3, TLN1, ROCK2, ACTB
	KEGG_TIGHT_JUNCTION	0.0657	MYH10, ACTN1, TJP1, EPB41L2, PPP2CB, MYH9, ACTN4
Reactome	–	–	–
Hallmark	HALLMARK_APICAL_JUNCTION	0.0076	MYH10, NEXN, ACTN1, TJP1, EPB41L2, MYH9, ACTA1, CNN2, VCL, ACTN4, PARVA
	HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION	0.0084	PLOD2, FGF2, COL1A2, TPM1, FERMT2, SERPINH1, TAGLN, DPYSL3, CALU, COL12A1, PCOLCE, COL6A2, FLNA, GJA1
Transcription factor targets	–	–	–
miRNA binding	TGTTTAC,MIR-30A-5P,MIR-30C,MIR-30D,MIR-30B,MIR-30E-5P	0.0806	PTGFRN, MYH10, VAT1, P4HA2, DOCK7, ITGA6, SEC23A, PPP1R12A, HSPA5, CALU, LPP, GFPT2, LIN7C, VAT1L, GJA1
GO biological process	–	–	–
GO cellular component	–	–	–
GO molecular function	–	–	–

Distinct gene set databases (column 1) were queried to identify gene sets (column 2) which are significantly (false discovery rate (FDR) q-value <0.1, column 3) VFF-enriched when comparing the protein expression profiles of VFF with OMF. Proteins (specified by gene symbol) detected in the VFF/OMF samples and having the strongest contribution to the enrichment result (“core enrichment”, as defined by the Gene Set Enrichment Analysis (GSEA) method) are listed in column 4.