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. 2016 Dec 6;45(6):3031–3045. doi: 10.1093/nar/gkw1222

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Published by Oxford University Press on behalf of Nucleic Acids Research 2016.

This work is written by (a) US Government employee(s) and is in the public domain in the US.

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Figure 1. — Loss of HMGNs down regulates the expression of genes involved in neural lineage differentiation. (A) HMGN2 protein expression during mouse embryonic preimplantation. Shown are immunofluorescence images at the stages indicated above each panel. (B) Morphology of WT and DKO ESCs colonies and differentiating embryoid bodies (EBs). (C) The number of significantly (fold change ≥ 1.5, P < 0.05) up (green) or down (red) regulated genes between WT and DKO ESCs and EBs at indicated stages. RNA-seq data were obtained from three independent ESC clones (biological replicates). (D) Gene ontology (GO) categories enriched for up (green) or down (red) regulated genes during ESCs differentiation. Number of changed genes in each category is shown in brackets.