TABLE 1.
Serum gliotoxin concentrations in unselected patients at risk for IA
| Classification and patient | Underlying malignancyb | Neutropeniac | Transplantationd | Computer tomography findings of IA | Culture | Serum gliotoxin (ng/ml) concn |
|---|---|---|---|---|---|---|
| No evidence of IAa | ||||||
| 1 | AML | No | Allo-MUD | NDg | Negative | ND |
| 2 | CLL | No | No | ND | Negative | ND |
| 3 | AML | No | Allo-MUD | ND | Negative | ND |
| 4 | Lung cancer | No | No | ND | Negative | ND |
| 5 | MDS | No | No | ND | Negative | ND |
| 6 | ALL | No | No | ND | Negative | 65 |
| 7 | AML | Yes | Allo-MUD | ND | Negative | ND |
| 8 | ALL | Yes | No | Lung-unilateral | Negative | ND |
| 9 | AML | No | No | ND | Negative | 154 |
| 10 | CML | No | Allo-MUD | Lung-aspergillomae | Negative | ND |
| 11 | AML | Yes | Allo-cord | Lung-unilateral | Negative | ND |
| Documented IAa | ||||||
| 12 | AML | No | No | Lung-bilateral | A. fumigatus | 785 |
| 13 | HL | No | Allo-MUD | Brain-single lesion | A. fumigatus | ND |
| 14 | AML | No | No | Lung-unilateral | A. terreus | 203 |
| 15 | ALL | No | Allo-MUD | Lung-bilateral | Histopathologyf | 166 |
| 16 | NHL | No | Allo-MRD | Lung-bilateral | Histopathologyf | 372 |
a
According to EORTC/NIAID/MSG criteria (1).
b
AML, acute myelogenous leukemia; ALL, acute lymphocytic leukemia; CLL, chronic lymphocytic leukemia; CML, chronic myelogenous leukemia; HL, Hodgkin's lymphoma; MDS, myelodysplastic syndrome; NHL, non-Hodgkin's lymphoma.
c
Neutropenia = absolute neutrophil count ≤ 500 at time of sampling.
d
Allo-MUD, allogeneic matched unrelated donor; Allo-MRD, allogeneic matched related donor; Allo-cord, Allogeneic umbilical cord stem cell source.
e
Diagnosed by computer tomography and patient history.
f
Histopathology, septal branching (45°) hyphae seen in tissue histopathology consistent with Aspergillus or Fusarium.
g
ND, not detected.