Figure 5.
Uracil N-glycosylase over-expression suppresses mutation outside AGCW motifs. Mean frequencies of (A) mutations at A:T, (B) transitions at C:G or (C) transversions at C:G per sequence for each host mouse that received adoptive SWHEL B cells transduced with (SMUG) SMUG1-expressing vector, (UNG) UNG2-expressing vector or (EV) empty pMiG vector. Open symbols: co-expression of native protein and GFP. Closed symbols: expression of SMUG1-GFP or UNG2-GFP fusion proteins. Bars indicate median ± inter-quartile range of the host means. Holm–Sidak's p-values are shown.