Figure 3.

BBR inhibited CVB3-induced activation of JNK and p38. HeLa cells and primary myocardial cells infected with CVB3 (MOI=3) for 1 h were treated with BBR at the indicated concentrations (10 μM, 25 μM, 50 μM, 100 μM) for 20 h. The phosphorylation levels of JNK, p38, and ERK in HeLa cells (A) and in primary myocardial cells (B) were analyzed by Western blot. The controls were treated with vehicle control (DMSO, 0.1%). (C) HeLa cells were infected with mock-control, CVB3, or UV-inactivated CVB3 (MOI=3). Representative data from triplicate experiments are shown. GAPDH was used as a loading control.