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. 2017 Jan 18;45(6):3580–3590. doi: 10.1093/nar/gkw1354

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© The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Metal binding sites. (A) Active site of the G20c nuclease complex with Zn²⁺. The two Mn²⁺ ions, taken from structure superposition with SPP1 and HCMV nuclease-Mn²⁺ complexes are in magenta and yellow, respectively. The water nucleophile is shown in cyan. (B) In vitro nuclease assays. Activity is shown for the wild-type and active site mutant proteins. N, nicked; L, linear; S, supercoiled DNA.