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. 2016 Dec 8;45(5):2408–2422. doi: 10.1093/nar/gkw1186

Figure 2.

Figure 2.

Evolution of the rs174557 locus. (A) Illustration of how the AluYe5 element and SNP rs174557 has evolved with multiple alleles detected in modern humans determined by PacBio sequencing in pooled genomic DNA from 500 samples. (B) Enhancer activity of all the alleles of rs174557 in human, the chimpanzee allele (Chimp) and the consensus sequence of AluYe5 element (Con). All the data came from three independent transfections each with six technical replicates. Error bars represent SD with ***P < 0.0001 calculated by two-tailed t tests when compared with the D allele of rs174557.