TABLE 5.

Multiple Variable Model Predicting Risk of Recurrence and Mortality

	RFS			OS
Variable	HR	95% CI	P	HR	95% CI	P
	EGC
Age	1.02	1.00 to 1.03	0.072	1.08	1.07 to 1.09	<0.001
Female	0.65	0.42 to 1.00	0.050	0.53	0.40 to 0.72	<0.001
Submucosal invasion	1.04	0.68 to 1.57	0.870	1.15	0.89 to 1.48	0.286
LN metastasis	6.00	3.95 to 9.02	<0.001	2.23	1.62 to 3.07	<0.001
Histology and grade
PD (vs WMD)	0.77	0.50 to 1.20	0.255	0.96	0.71 to 1.29	0.772
SRC (vs WMD)	0.37	0.19 to 0.71	0.003	0.66	0.44 to 0.98	0.041
	AGC
Age	1.00	1.00 to 1.01	0.138	1.02	1.02 to 1.03	<0.001
Female	1.09	0.96 to 1.24	0.168	1.04	0.93 to 1.17	0.490
AJCC stage
Stage II (vs stage I)	3.67	2.47 to 5.46	<0.001	2.12	1.60 to 2.81	<0.001
Stage III (vs stage I)	13.87	9.52 to 20.21	<0.001	6.89	5.32 to 8.93	<0.001
Histology and grade
PD (vs WMD)	1.14	0.99 to 1.31	0.063	1.23	1.09 to 1.40	0.001
SRC (vs WMD)	1.22	1.02 to 1.46	0.033	1.45	1.22 to 1.71	<0.001

AGC indicates advanced gastric cancer; CI, confidence interval, EGC, early gastric cancer; HR, hazard ratio; LN, lymph node; PD, poorly differentiated; RFS, Relapse-free survival; SRC, signet ring cell carcinoma; WMD, well-to-moderately differentiated.