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. 2017 Jan 28;45(6):3369–3377. doi: 10.1093/nar/gkx050

Figure 4.

Figure 4.

Deamination in the DNA strand of DNA/RNA hybrid duplexes; effects of mismatches and duplex length. (A) Sequence surrounding three editing sites (A, B and C). Red color indicates DNA. Black corresponds to sequence of 24 nt RNA bottom strand with varying X and Y positions. Gray corresponds to 93 nt RNA bottom strand. (B–F) Percent editing for sites A, B and C in the different substrate structures shown with either hADAR2 wt or hADAR2d E488Q. Statistical significance between groups was determined by t tests. (***P-value ≤ 0.001, **P-value ≤ 0.01, *P-value ≤ 0.05).