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Selective editing of multiple sites in the ssDNA genome from M13 bacteriophage. (A) Single-stranded DNA and six target sites. Target sites are shown in red. Guide RNAs are shown in green. (B) Percent editing by 500 nM hADAR1d E1008Q at each site. (C) Off target site found adjacent to AAT target. Off target site is marked with an asterisk in sequence trace. Statistical significance between groups was determined by t tests (***P-value ≤ 0.001, **P-value ≤ 0.01, *P-value ≤ 0.05).
