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Enrichment of differentially methylated regions. (A) Sixteen most enriched transcription factor binding sites for hypermethylated regions and (B) hypomethylated regions respectively. (C) Tumour-Normal methylation differences chr22 show large hypomethylated blocks (LHB). Black dots represent mean methylation difference between PDX and normal, dashed lines are smoothed methylation differences for individual patients. Violet bars indicate two LHB, abundant in most of the tumour samples.
