Figure 2.

Characterization of the model for inferring snoRNA–target interactions from chimeric reads. (A) Empirical cumulative distribution function of the interaction energy estimated with PLEXY between target fragment and snoRNA found in the chimera ('Real chimeras') or between target fragment and a randomly assigned snoRNA ('Shuffled snoRNA'). P-value from the Mann–Whitney U test is also shown. (B) Metrics illustrating the performance of the method, as a function of the minimum average probability of the considered sites from the 18S and 28S rRNAs. (C) Precision-Recall curve for the method. (D) Matthews correlation coefficient (MCC) as a function of the minimum average probability of the considered sites.