TABLE 1.
Protection after challenge with wild-type S. flexneri 2a 2457T
| Immunizing strain | No. of eyes inoculated | No. of eyes with the indicated ratinga
|
% Protectionb
|
|||||
|---|---|---|---|---|---|---|---|---|
| 0 | 1 | 2 | 3 | F | P | C | ||
| Normal saline | 8 | 0 | 1 | 1 | 6 | 0 | 0 | 0 |
| SC608(p3098) | 16 | 9 | 5 | 2 | 0 | 56.3 | 31.2 | 87.5 |
| SC608(pCFAI) | 16 | 13 | 3 | 0 | 0 | 81.3 | 18.7 | 100 |
| SC608(pCFAI/LTB) | 16 | 12 | 2 | 2 | 0 | 75.0 | 12.5 | 87.5 |
a
0, no inflammation or mild disease; 1, mild keratoconjunctivitis; 2, keratoconjunctivitis without purulence; 3, severe keratoconjunctivitis with purulence.
b
F, full; P, partial; and C, combined.