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. 2016 Dec 13;45(4):1860–1871. doi: 10.1093/nar/gkw1210

Figure 2.

Figure 2.

Domain organization of RMI1 and TOP3α proteins in representative eukaryotic species. (A) Schematic representation of RMI1 proteins in representative eukaryotic species. In most species, RMI1 protein contains three conserved domains: a domain of unknown function DUF1767 and two Oligo binding (OB)-fold domains. The second OB-fold domain 2 is not conserved in the yeast lineage. Positions of the mutations described in Arabidopsis are indicated. Triangles show the T-DNA insertion sites and point mutations are indicated with a star. The corresponding protein alignment is shown in Supplemental Figure S1. (B) Domain organization of TOP3α/Top3 proteins in representative eukaryotic species. Positions and nomenclature of the different domains are based on the human protein architecture described by Bocquet et al. (44). The Toprim domain, the gate domain (II), the catalytic 5Y cap (III) and the noncatalytic CAP domain (IV) are conserved in all species. Aside from the yeast lineage, TOP3α proteins contain from one up to five zinc finger domains. Positions of the mutations described in Arabidopsis are indicated as in (A). The corresponding protein alignment is shown in Supplemental Figure S1.