TABLE 1.
Titers of antibodies against different AMA1 constructs in Wosera individuals
| Age group (yr) or total no. of individuals | % Positive serum samples (median antibody titer)b
|
||||||
|---|---|---|---|---|---|---|---|
| Domain II, 3D7 | Domain III
|
Full ectodomain
|
|||||
| 3D7 | D10 | HB3 | 3D7 | D10 | HB3 | ||
| Total (n = 262) | 32 (3,696) | 31 (1,735) | 31 (1,676) | 30 (2,034) | 84 (46,738) | 85 (57,551)a | 84 (51,807) |
| Age group | |||||||
| 0-2 (n = 31) | 10 (1,752) | 6 (2,032) | 3 (3,901) | 0 (0) | 52 (11,221) | 52 (13,807) | 55 (11,564) |
| 3-9 (n = 109) | 24 (3,746) | 11 (1,624) | 13 (1,405) | 13 (1,643) | 77 (23,520) | 78 (24,706)a | 77 (23,916) |
| 10-19 (n = 66) | 39 (5,087) | 38 (1,281) | 38 (1,482) | 36 (2,087) | 98 (78,326) | 98 (83,953)a | 97 (71,955) |
| >20 (n = 56) | 50 (3,466) | 75 (1,798) | 71 (1,793) | 71 (2,047) | 100 (103,860) | 100 (108,664) | 100 (110,703) |
a
Titer significantly higher (P < 0.05) than the titer against an alternative form of the same construct (using Wilcoxon signed-rank test).
b
Median antibody titer in positive samples only.