FIG. 1.

Spirochete levels in tissue of immunodeficient mice. Mice were infected with B. burgdorferi and sacrificed at 2, 4, and 8 weeks postinfection. All groups contained five mice, except the scid group, which had four mice per time point. Statistical analysis was performed by one-way analysis of variance using SPSS software (SPSS Inc., Chicago, Ill.) followed by Tamhane post hoc multiple comparison. Significant difference was defined as P < 0.05. Values for mutant mice that were significantly greater than those for wild-type mice are indicated by *. Values for wild-type and single-mutant mice that were significantly less than those for TLR2^−/−/scid mice are indicated by ‡.