FIG. 2.

Rear ankle swelling in B. burgdorferi-infected mice. The rear ankles of B. burgdorferi-infected mice were measured, and the ankle swelling data were obtained by subtracting the ankle diameter at 4 weeks postinfection from the preinfection diameter (35). Results from three experiments are shown, with the C57BL/6, scid, TLR2^−/−, and TLR2^−/−/scid groups containing 15, 12, 16, and 16 mice, respectively. Statistical analysis was performed by one-way analysis of variance followed by Tamhane post hoc multiple comparison, and significant difference was defined as P < 0.05. Values that were significantly different from C57BL/6 are indicated by *. The ankle swelling observed in TLR2^−/− mice was significantly greater than the swelling seen in any other group and is indicated by ‡.