Clinical descriptors of our cohort capture the overlaps and distinctions among CF, CFTR-RD, and CRMS. Sweat chloride measurements are from the time point closest to diagnosis. CF, cystic fibrosis; CFTR-RD, cystic fibrosis transmembrane conductance regulator-related disorder; CRMS, CFTR-related metabolic syndrome; PI, pancreatic insufficient; PS, pancreatic sufficient.