Table 3.
Cumulative Physiologic Dysfunction Component Cut-Points in Pregnancy (N=111) a
| Component | 75th Percentile | Clinical Cut-Point |
|---|---|---|
| CRPb (Inflammatory) | ≥2.07 mg/mL | variable |
| IL6 (Inflammatory) | ≥0.63 pg/mL | variable |
| Total Cholesterol (Metabolic) | ≥193.70 ng/mL | >200 ng/mL |
| Systolic Blood Pressure (Cardiovascular) | ≥120 mmHg | ≥140 mmHg |
| Diastolic Blood Pressure (Cardiovascular) | ≥71 mmHg | ≥90 mmHg |
| Early Pregnancy BMIc (Metabolic) | ≥28.30 kg/m2 | 25-30 kg/m2 (overweight) |
| ≥30 kg/m2 (obese) | ||
| Glucose Toleranced (Metabolic) | ≥125.5 mg/dL | ≥100 mg/dL with re-testing |
| Urinary protein (Kidney Function) | Presence of any | n/a |
a
Components were constructed from the prenatal visit closest to the dried blood spot collection in the third trimester (≥28 weeks gestation).
b
High risk categorization constructed using cut-points for ≥ 75th percentile for each component.
c
Based on a pre-pregnancy weight or pregnancy weight ≤14 weeks gestation.
d
Based on the one-hour glucose challenge (50 gm) Clinical diagnosis involves serial testing for glucose tolerance.
CRP=C-reactive protein
IL6= Interleukin 6
BMI=Body Mass Index