Table 3. Association of urine angiotensinogen, gremlin-1, and urine and serum MMP-7 with mortality.

	Events	Unadjusted IR (per 100 pys)	Unadjusted HR (95% CI)	Model 1 HR (95% CI)	Model 2 HR (95% CI)	Model 3 HR (95% CI)
Urine angiotensinogen/creatinine
Tertile 1	16	8.7	1.06 (0.52, 2.17)	0.83 (0.39, 1.76)	1.04 (0.42, 2.58)	1.92 (0.59, 6.29)
Tertile 2	9	5.1	0.62 (0.26, 1.44)	0.53 (0.23, 1.22)	0.51 (0.22, 1.19)	0.6 (0.17, 2.04)
Tertile 3	14	8.4	Ref	Ref	Ref	Ref
Per doubling			0.97 (0.92, 1.02)	0.97 (0.92, 1.03)	0.95 (0.89, 1.01)	0.9 (0.84, 0.96)
p-value			0.19	0.34	0.081	0.0012
Urine gremlin-1/creatinine
Tertile 1	9	5.1	Ref	Ref	Ref	Ref
Tertile 2	15	9.4	1.81 (0.81, 4.02)	2.07 (0.92, 4.65)	1.85 (0.85, 4.05)	1.46 (0.57, 3.76)
Tertile 3	15	8	1.58 (0.68, 3.67)	2.02 (0.87, 4.66)	1.87 (0.83, 4.36)	1.2 (0.46, 3.13)
Per doubling			1.06 (0.94, 1.2)	1.1 (0.97, 1.25)	1.1 (0.96, 1.27)	1 (0.85, 1.18)
p-value			0.32	0.13	0.17	0.99
Urine MMP-7/creatinine
Tertile 1	9	5.3	Ref	Ref	Ref	Ref
Tertile 2	13	6.9	1.35 (0.59, 3.08)	2 (0.89, 4.47)	1.71 (0.71, 4.07)	2.82 (1.04, 7.6)
Tertile 3	17	10.2	1.94 (0.86, 4.34)	3.08 (1.31, 7.22)	2.67 (1.08, 6.55)	3.59 (1.31, 9.85)
Per doubling			1.18 (0.95, 1.46)	1.33 (1.07, 1.66)	1.31 (1.03, 1.67)	1.37 (1.04, 1.81)
p-value			0.13	0.01	0.025	0.025
Serum MMP-7
Tertile 1	12	6.2	Ref	Ref	Ref	Ref
Tertile 2	13	7.1	1.18 (0.54, 2.59)	1.32 (0.61, 2.85)	1.64 (0.76, 3.57)	0.95 (0.4, 2.22)
Tertile 3	15	7.9	1.32 (0.62, 2.81)	1.24 (0.57, 2.69)	1.52 (0.65, 3.55)	0.88 (0.34, 2.33)
Per doubling			1.28 (0.89, 1.85)	1.3 (0.92, 1.84)	1.48 (1.01, 2.17)	1.19 (0.75, 1.89)
p-value			0.19	0.13	0.046	0.46

Tertiles for urine angiotensinogen, gremlin-1, MMP-7 and serum MMP-7 are as described in Table 2. Models 1-3 were adjusted as described in Table 2. HR: hazard ratio; 95% CI: 95% confidence interval. The p-values are for doubling.