Table 1.

Laboratory characteristics of SCA patients taking and not taking hydroxyurea (HU)

Laboratory value	All patients	No HU use*	HU *	p value*
	N=141	N=99	N=42
	Median (25th – 75th)	Median (25th – 75th)	Median (25th – 75th)
RBC, ×1012/L	2.4 (2.2 – 2.8)	2.6 (2.3 – 2.8)	2.2 (2.0 – 2.6)	0.004
Hemoglobin, g/dL	7.7 (7.2 – 8.7)	7.6 (7.2 – 8.5)	8.0 (7.3 – 9.2)	0.206
Hematocrit, %	22.0 (20.0 – 25.0)	21.8 (20.0 – 24.4)	22.4 (19.6 – 25.2)	0.757
MCV, fL	89.2 (83.6 – 96.3)	86.2 (81.4 – 90.9)	97.2 (90.7 – 103.4)	<0.001
Total bilirubin, mg/dL	2.4 (1.6 – 3.5)	2.6 (1.7 – 3.8)	2.1 (1.5 – 3.0)	0.084
Direct bilirubin, mg/dL	0.4 (0.3 – 0.6)	0.4 (0.3 – 0.6)	0.4 (0.3 – 0.5)	0.501
Indirect bilirubin, mg/dL	2.0 (1.2 – 3.0)	2.2 (1.2 – 3.2)	1.6 (1.1 – 2.5)	0.072
LDH, U/L	999.0 (738.5 – 1586.5)	1094.0 (791.0 – 1710.0)	897.0 (677.2 – 1480.5)	0.101
HbF, %	9.9 (5.7 – 14.6)	9.3 (5.2 – 14.1)	11.1 (9.0 – 15.4)	0.013
HbF, g/dL	0,76 (0,43 – 1,10)	0,71 (0,40 – 1,09)	0,85 (0,69 – 1,20)	0.010
HbS, %	85.4 (81.1 – 90.0)	86.7 (81.2 – 91.5)	83.6 (80.3 – 86.6)	0.007
WBC, × 109/L	12700.0 (9700.0 – 15600.0)	13900.0 (11200.0 – 16100.0)	9700.0 (8050.0 – 12800.0)	<0.001
Neutrophils, × 109/L	5396.0 (4005.0 – 7153.0)	5760.0 (4081.0 – 7182.0)	4839.0 (3684.5 – 6705.7)	0.102
Eosinophil count, × 109/L	642.0 (249.0 – 1541.0)	696.0 (282.0 – 1807.0)	394.5 (146.0 – 738.0)	0.001
Lymphocyte count, × 109/L	4998.0 (3918.0 – 6726.5)	5560.0 (4350.0 – 7224.0)	4156.5 (3329.2 – 5085.0)	<0.001
Monocyte count, × 109/L	338.0 (200.0 – 611.5)	360.0 (220.0 – 688.0)	279.5 (156.7 – 517.5)	0.045

RBC: red blood cell; MCV: mean cell volume; LDH: lactate dehydrogenase; WBC: white blood cell. p-value obtained using Mann-Whitney and *p-value using t test.

Bold values indicate significance at p < 0.05 between patients not using and using HU.