TABLE 5.
Genes (53) that are upregulated 4 h following K. pneumoniae infection and are unique to C3H/HeN mice
| Affymetrix probe ID | Gene symbol | GenBank accession no. | Mean change (fold) in C3H/HeN mice at 4 vs 0 h | Results in C57BL/6 mice at 4 vs 0 ha | Description |
|---|---|---|---|---|---|
| 99367_at | EST | AA434661 | 9.1 | NS | IMAGE-818356 |
| 94375_at | Hk2 | Y11666 | 4.2 | Fld<2 | Hexokinase 2 |
| 103891_i_at | El12 | AI197161 | 4.1 | Fld<2 | Elongation factor RNA polymerase II |
| 92294_at | EST | AW060793 | 3.6 | NS | Unknown |
| 100302_at | Maff | AB009694 | 3.4 | Chg | v-Maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) |
| 104701_at | Bhlhb2 | Y07836 | 3.2 | Fld<2 | Basic helix-loop-helix domain containing, class B2 |
| 103438_at | Dio2 | AF096875 | 2.8 | NS | Deiodinase, iodothyronine, type II |
| 97142_at | EST | C80153 | 2.7 | Chg | Unknown |
| 99864_at | Adora2b | AA608277 | 2.7 | Chg | Adenosine A2b receptor |
| 103892_r_at | EST | AI197161 | 2.6 | Fld<2 | IMAGE-1494691 |
| 99529_f_at | Rnf138 | AB025011 | 2.6 | NS | Ring finger protein 138 |
| 104612_g_at | Wdr26 | AI854008 | 2.6 | Fld<2 | WD repeat domain 26 |
| 92738_at | Gdnf | D49921 | 2.6 | NS | Glial cell line-derived neurotrophic factor |
| 102984_g_at | Madh1 | U58992 | 2.1 | Fld<2 | MAD homolog 1 |
| 160095_at | Lox | D10837 | 2.5 | NS | Lysyl oxidase |
| 95681_f_at | Ppplr2 | AW049584 | 2.5 | Chg | Protein phosphatase I, regulatory subunit 2 |
| 93981_at | Plat | J03520 | 2.4 | Chg | Plasminogen activator |
| 99032_at | Rasd1 | AF009246 | 2.4 | NS | RAS, dexamethasone induced 1 |
| 97740_at | Dusp16 | A1642662 | 2.4 | Fld<2 | Dual specificity phosphatase 16 |
| 95978_at | EST | AA414964 | 2.4 | Chg | Unknown |
| 93882_f_at | Tgoln2 | D50032 | 2.4 | Chg | trans-Golgi network protein 2 |
| 97890_at | Sgk | AW046181 | 2.4 | Fld<2 | Serum/glucocorticoid-regulated kinase |
| 103362_at | Ptger4 | D13458 | 2.4 | Fld<2 | Prostaglandin E receptor 4 (subtype EP4) |
| 94489_at | Prp4aI | U84411 | 2.3 | Fld<2 | Protein tyrosine phosphatase 4a 1 |
| 102292_at | Gadd45a | U00937 | 2.3 | Fld<2 | Growth arrest and DNA-damage-inducible 45 alpha |
| 104534_at | Pgm1 | AA623974 | 2.3 | Fld<2 | Phosphoglucomutase 1 |
| 98892_at | Lpin1 | AI846934 | 2.3 | NS | Lpin1 |
| 104494_at | EST | AI642098 | 2.3 | NS | Unknown |
| 103062_at | Rab33b | AB004664 | 2.3 | NS | RAB33B, member of RAS oncogene family |
| 96777_at | Sf3b1 | AW049372 | 2.2 | NS | Splicing factor 3b, subunit 1 |
| 100065_r_at | Gja1 | M63801 | 2.2 | Fld<2 | Gap junction membrane channel protein alpha 1 |
| 94378_at | Rgs16 | U94828 | 2.2 | Fld<2 | Retinally abundant regulator of G-protein signaling mRGS-r |
| 104257_g_at | Pscdbp | AI120844 | 2.2 | Fld<2 | Pleckstrin homology, Sec7, and coiled-coil domains, binding protein |
| 94088_at | Ptbp2 | AW228429 | 2.2 | Chg | Polypyrimidine tract binding protein 2 |
| 98540_g_at | Cops2 | AF071312 | 2.2 | Chg | COP9 (constitutive photomorphogenic homolog), subunit 2 |
| 94662_at | EST | AA409766 | 2.2 | NS | Unknown |
| 100010_at | Klf3 | U36340 | 2.2 | NS | Kruppel-like factor 3 |
| 98608_at | Etf1 | AI845886 | 2.1 | Fld<2 | Eukaryotic translation termination factor 1 |
| 93471_at | Slc4a7 | AI594427 | 2.1 | Chg | Solute carrier family 4, sodium bicarbonate cotransporter, member 7 |
| 100064_f_at | Gja1 | M63801 | 2.1 | Fld<2 | Gap junction membrane channel protein alpha 1 |
| 100509_at | Rnf19 | AW121012 | 2.1 | Fld<2 | Ring finger protein 19 |
| 92638_at | Ppp2ca | Z67745 | 2.1 | NS | Protein phosphatase 2a, catalytic subunit alpha isoform |
| 103708_at | Eifla | AI132207 | 2.1 | Fld<2 | Eukaryotic translation initiation factor 1A |
| 104340_at | Mbd1 | AF072240 | 2.1 | Fld<2 | Methyl-CpG binding domain protein 1 |
| 101437_at | Stk2 | AF039574 | 2.1 | NS | Serine/threonine kinase 2 |
| 103451_at | Ptk2b | AI835159 | 2.0 | Chg | PTK2 protein tyrosine kinase 2 beta |
| 100297_at | Wdr26 | AA693125 | 2.0 | NS | WD repeat domain 26 |
| 98946_at | Wsb-1 | AF033186 | 2.0 | Fld<2 | WD-40-repeat-containing protein with a SOCS box 1 |
| 99087_at | D10Ertd749e | AW060179 | 2.0 | Chg | DNA segment chromosome 10 |
| 103028_at | Itk | D14042 | 2.0 | NS | IL-2-inducible T-cell kinase |
| 103614_at | Nfkb2 | AW047899 | 2.0 | Fld<2 | Nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 |
| 94415_at | EST | AA710439 | 2.0 | Fld<2 | IMAGE-1165752 |
| 103288_at | Nrip1 | AF053062 | 2.0 | NS | Nuclear receptor-interacting protein 1 |
a
Fold changes were not shown for those genes that had detection calls of absent (A) in the 4-h treated group; that had an inappropriate change call (Chg), such that there was not a call of increased or marginally increased in greater than half of the comparisons made; that had a fold change less than 1 (Fld<2); or that were not determined to be significant by parametric and nonparametric tests with a P cutoff value of ≤0.05.