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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Traffic. 2017 Mar 23;18(5):267–276. doi: 10.1111/tra.12477

Figure 1. Parallels between C9orf72:SMCR8 and FLCN:FNIP complexes.

Figure 1

A) Summary of the predicted domain organization of C9orf72, FNIP1, SMCR8 and C9orf72 that illustrates that the DENN domain represents the major folded element in each of these proteins. Also noted at the N-terminal region of each of these DENN domains is a region that has similarity to the Longin domain that is found in many GTPase regulating proteins. B) WDR41 is predicted to contain 8 WD40 repeats62. C) Schematic diagram summarizing functions and lysosomal localization of the C9orf72:SMCR8:WDR41 and FLCN:FNIP complexes.