Figure 3.

The SAXS-ER results for the free SAM-1 aptamer. (a) The minimal χ and the corresponding 〈R_g〉 at each cycle. The final selected ensemble at the 23rd is indicated by a red triangle. (b) The conformers in the final ensemble, which are superimposed on the subdomain P4 (nucleotides 69–82, colored in blue). The location of SAM is approximated by a red star. (c) The back-calculated SAXS profile of the final ensemble (black) is fitted to the experimental data (red). To see this figure in color, go online.