Figure 2.

Stress and strain stiffening: Scatter plot of t_entry versus ε_max/Δp for 19,991 K562 cells as in Fig. 1c. (Black squares connected by red lines) Median values of t_entry versus ε_max/Δp for different pressure and strain bins with at least 250 cells in each bin, with a strain bin width of 0.03, a pressure bin width of 50 Pa, and median pressure and strain values as indicated by the numbers next to the grid lines. (Black grid) Fit of Eq. 1 to the binned data, with stress stiffening according to E = E₀ + c₁ Δp. Fit parameters are E₀ = 58 Pa, c₁ = 1.11 Pa⁻¹, and β = 0.07. To see this figure in color, go online.