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. 2017 Apr 13;8:439. doi: 10.3389/fimmu.2017.00439

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Copyright © 2017 Panda, Krieger, Hopf, Renné, Haag, Röber, Conrad, Csernok and Fuchs.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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P-ANCAs and C-ANCAs stain the cytoplasm of unstimulated neutrophils. (A–C) Staining of naïve neutrophils. Top panel shows human IgG staining (green), and bottom panel shows overlay of human IgG (green) and DNA staining (white). DNA staining of unstimulated neutrophils shows lobulated nuclei. Bar represents 20 µm. (A) Naïve neutrophils incubated with P-ANCA-positive sera and (B) C-ANCA-positive sera give a cytoplasmic staining pattern. (C) No staining was observed with autoantibody-negative sera (Ctrl). Images are representative of at least three independent experiments.