Table 1.
Thymic epithelial cells (TEC) DNA damage response gene expression analysis.
| mTEC 21% O2 relative to cTEC 21% O2 |
mTEC 21% O2 relative to mTEC 5% O2 |
cTEC 21% O2 relative to cTEC 5% O2 |
||||||
|---|---|---|---|---|---|---|---|---|
| Gene symbol | Fold regulation | p-Value | Gene symbol | Fold regulation | p-Value | Gene symbol | Fold regulation | p-Value |
| Cdkn1a | 9.7867 | 0.049561 | Rpa1 | 6.6947 | 0.4525 | Ogg1 | −2.2717 | 0.068328 |
| Ogg1 | 6.69 | 0.027358 | Mbd4 | 2.6039 | 0.086309 | |||
| Gadd45a | 5.5777 | 0.018754 | Fancc | 2.4879 | 0.306775 | |||
| Mbd4 | 5.112 | 0.001134 | Mlh1 | 2.4701 | 0.709673 | |||
| Cdc25c | 5.0346 | 0.000334 | Ppp1r15a | 2.1235 | 0.296088 | |||
| Parp2 | 4.83 | 0.047262 | Ddit3 | 2.0463 | 0.380959 | |||
| Xpc | 4.698 | 0.042352 | Lig1 | 1.4897 | 0.031506 | |||
| Ppp1r15a | 4.2181 | 0.09951 | Rad18 | 1.3287 | 0.042163 | |||
| Xpa | 3.9535 | 0.021999 | ||||||
| Prkdc | 3.8944 | 0.001389 | ||||||
| Rad51b | 3.8334 | 0.005391 | ||||||
| Fancd2 | 3.8197 | 0.029257 | ||||||
| Fancg | 3.7531 | 0.0874 | ||||||
| Abl1 | 3.6328 | 0.121405 | ||||||
| Xrcc1 | 3.4676 | 0.078948 | ||||||
| Rad1 | 3.3607 | 0.004642 | ||||||
| Chek1 | 3.3356 | 0.014122 | ||||||
| Fen1 | 3.2154 | 0.157843 | ||||||
| Lig4 | 3.1376 | 0.042301 | ||||||
| Trp53 | 3.1171 | 0.078992 | ||||||
| Nbs1 | 3.043 | 0.001907 | ||||||
| Msh2 | 2.9736 | 0.022276 | ||||||
| Ercc1 | 2.9049 | 0.042759 | ||||||
| Bcl2 | 2.7883 | 0.177894 | ||||||
| Xrcc2 | 2.6866 | 0.096181 | ||||||
| Brca2 | 2.618 | 0.00031 | ||||||
| Apex1 | 2.6124 | 0.11235 | ||||||
| Ung | 2.5834 | 0.252669 | ||||||
| Rad52 | 2.4769 | 0.016033 | ||||||
| Rpa1 | 2.4658 | 0.305147 | ||||||
| Rnf8 | 2.4384 | 0.197479 | ||||||
| Trp53bp1 | 2.3941 | 0.161481 | ||||||
| Rad9a | 2.3515 | 0.170914 | ||||||
| Rad21 | 2.3323 | 0.058508 | ||||||
| Xrcc3 | 2.2615 | 0.152825 | ||||||
| Rad17 | 2.2565 | 0.000658 | ||||||
| Topbp1 | 2.2545 | 0.223298 | ||||||
| Atm | 2.1819 | 0.277075 | ||||||
| Hus1 | 2.1729 | 0.122838 | ||||||
| Nthl1 | 2.1645 | 0.174959 | ||||||
| Blm | 2.1445 | 0.02165 | ||||||
| Msh3 | 2.1212 | 0.147084 | ||||||
| Rad51c | 2.0965 | 0.014677 | ||||||
| Mpg | 2.0873 | 0.170764 | ||||||
| Ppm1d | 2.0701 | 0.027739 | ||||||
| Pole | 2.0584 | 0.300385 | ||||||
| Mdc1 | 2.0072 | 0.071037 | ||||||
| Mif | 1.9804 | 0.016166 | ||||||
| Smc3 | 1.8309 | 0.022549 | ||||||
| Dclre1a | 1.825 | 0.005796 | ||||||
| Atr | 1.7345 | 0.027855 | ||||||
| Ddb2 | 1.6814 | 0.009335 | ||||||
| Rad50 | 1.5847 | 0.000778 | ||||||
| Brca1 | 1.5164 | 0.043145 | ||||||
List of genes showing greater than twofold up- or downregulation and/or p value lower than 0.05 in normoxic mTEC 3–10 vs. cTEC 1–2 (first column), normoxic vs. hypoxic mTEC 3–10 (second column) and normoxic vs. hypoxic cTEC 1–2 cells (third column). p values lower than 0.05 and expression fold changes greater than 2 are highlighted in bold.