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. 2017 Apr 13;8:438. doi: 10.3389/fimmu.2017.00438

Figure 1.

Figure 1

Schematic diagram of the downstream signaling pathway of cytokines sharing the common γ chain receptor: IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. All depend on the same set of Janus kinases (JAKs), JAK1 and JAK3, but may use a different combination signal transducer and activator of transcription (STATs). When cytokines bind to their respective receptors, JAK–STAT phosphorylation occurs. JAK inhibitors blocking JAK1, JAK3, or both are shown. NK cells and ILC1 depend on IL-15, while ILC2 and lymphoid tissue inducer (LTi)-like cells require IL-7 for development and maintenance. Finally, NCR+ ILC3 subset relies on IL-7 and IL-15.