Figure 1.

Ascl1 domain organization, structure prediction, and fragment design. (a) The disorder tendency was computed with the IUPred software (18, 29), whereas (b) the helical propensity prediction was obtained from Agadir (19). Peculiar sequence features of Ascl1, such as the polyA, polyQ, and Ser-Pro regions, as well as the bHLH domain, are highlighted. (c) The different fragments used in this study are shown at the bottom using a color code that is maintained throughout the manuscript. To see this figure in color, go online.