Table 1.

Best-fit Parameters for NN-na Model of Trp Cooperativity

NN	ΔGcoupling	ΔGbind	ΔHcoupling	ΔHbind	ΔCp,coupling	ΔCp,bind	Kd
	kcal mol−1		kcal mol−1		kcal mol−1 K−1		μM
0	—	−7.70 ± 0.21a	—	−13.5 ± 1.4a	—	0.10 ± 0.10a	4.24 ± 0.12
1	−1.04 ± 0.22a	−8.74 ± 0.21	−6.11 ± 1.0a	−19.7 ± 1.2	−0.49 ± 0.10a	−0.39 ± 0.10	0.80 ± 0.24
2	−1.15 ± 0.22a	−8.85 ± 0.21	−4.67 ± 1.4a	−18.2 ± 1.4	−0.45 ± 0.11a	−0.39 ± 0.10	0.67 ± 0.18

Globally fit parameters are given at a reference temperature of 40°C (313.15 K). Confidence intervals were obtained via bootstrapping with 200 replicates. NN, number of occupied nearest neighbors. Unless otherwise indicated, terms were obtained from the sum of the reference state (e.g., ΔG₀) and coupling terms (e.g., ΔG_oe and ΔG_oo). Equilibrium constants from ΔG_bind = RT ln K_d at 40°C.

^aFitted term.