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Representative Anti-PA IgM and IgG antibody titers in AVA-vaccinated humans and macaques. Transient anti-PA IgM antibodies and increasing anti-PA IgG antibody levels are observed after three doses of AVA (↓) at 0, 7, and 14 days. Anti-PA IgG titers decline until the first AVA booster at 180 days and then increase and remain high before and after the second and third AVA boosters at 12 and 18 months.
