Table 3. Residues of Tyr and P-Y in the potential PtpA substrates.
| Protein accession | Protein name | Targeting signala | Tyr in the targeting signal | Tyr in the human overall sequence |
|---|---|---|---|---|
| ECHA_HUMAN | Trifunctional enzyme subunit alfa | >sp|P40939|1–35 MVACRAI-GILSRFSAFRILRS-RGYICRNFTGSSALL | Y24 | Y24, Y43, Y158, Y239, Y271, Y283, Y298, Y320, Y343, Y435, Y499, Y546, Y637, Y639, Y724, Y736, Y740, Y762 |
| SQRD_HUMAN | Sulfide quinone oxidoreductase | >sp| Q9Y6N5 1–66 MVPLVAVV-SGPRAQLFAC-LLRLGTQQVG-PLQLHTGASH-AARNHYEVLV-LGGGSGGITM-AARMKRK | Y44 | Y44, Y82, Y138, Y140, Y151, Y170, Y210, Y215, Y242, Y259, Y289, Y228, Y373, Y376, Y385, Y395, Y415, Y426, Y434 |
| ATPA_HUMAN | ATP synthase subunit α | >sp|P25705|1–43 MLSVRVAAA-VVRALPRR-AGLVSRNAL-GSSFIAARNF-HASNTHL | N | Y243, Y246, Y271, Y287, Y291, Y299, Y311, Y321, Y337, Y343, Y380, Y401, Y440, Y476, Y489, Y495 |
| K6PP_HUMAN | 6-phosphofructokinase platelet type | NA | NA | Y52, Y58, Y61, Y56, Y162, Y164, Y223, Y298, Y394, Y447, Y487, Y512, Y586, Y589, Y604, Y645, Y651, Y654, Y764, Y768 |
aExtracted from the online resource UniProt58 or predicted with MitoProt II59. In bold, tyrosine residues noted up to now as phosphorylated in the online resource PhosohoSitePlus (http://www.phosphosite.org)34. N: None tyrosine in the mitochondrial targeting signal. NA: Not Apply.