Figure 7.

Control of Lineage Specification and Cell-Type Stratification during Prostate Development

(A) During normal prostate development, basal (red) cells generate both the basal and luminal lineages using symmetric and asymmetric cell divisions. In addition, double-positive cells (yellow) are generated from basal cells and contribute to the formation of the luminal lineage (green).

(B) Upon loss of Gata3 or treatment with ATM, spindle orientation is randomized, leading to an increase in the number of intermediate progenitor cells. Increased intermediate progenitor cells contribute to an expanded luminal layer and prostate epithelial hyperplasia.