TABLE 3.
Effect of elg1Δ on the rate of accumulating GCRs in different GCRa mutator strains
| Relevant genotype | Wild type
|
elg1Δ
|
||
|---|---|---|---|---|
| Strain | GCR rate, 1010 (Canr 5-FOAr) | Strain | GCR rate, 1010 (Canr 5-FOAr) | |
| Wild type | RDKY3615 | 3.5 (1) | YKJM1405 | 173 (49) |
| rad27Δ | RDKY3630 | 4,400 (1,257) | YKJM1677 | 5,795 (1,655) |
| rfa1-t33 | RDKY3617 | 4,700 (1,342) | YKJM1675 | 5,420 (1,540) |
| srs2Δ | RDKY3749 | >3.2 (1) | YKJM1667 | 112 (32) |
| yku70Δ | RDKY3731 | 4.1 (1.1) | YKJM1673 | >4.0 (1) |
| cac1Δ | RDKY4753 | 1,200 (343) | YKJM1592 | 5,880 (1,680) |
| asf1Δ | RDKY4756 | 250 (71) | YKJM2197 | 4,650 (1,328) |
| pif1-m2 | RDKY4343 | 630 (180) | YKJM1403 | 3,000 (857) |
| est2Δ | RDKY3745 | >2.2 (1) | YKJM1594 | 68 (19) |
| rif1Δ | RDKY4361 | 9.9 (3) | YKJM1889 | 210 (60) |
a
All strains are isogenic with wild-type strain RDKY3615 (ura3-52 leu2Δ1 trp1Δ63 his3Δ200 lys2ΔBgl hom3-10 ade2Δ1 ade8 hxt13::URA3) with the exception of the indicated mutations. The values in parentheses are GCR induction relative to the wild-type GCR rate.