Table 2. Down regulated cellular proteins in HEY Oct4A KD cells according to cellular function.
| Category | Gene Name | Protein Description | Rsc | *Reference |
|---|---|---|---|---|
| Cytoskeletal | TUBB2A | Tubulin beta-2A chain | -42.9 | (McCarroll and Kavallaris, 2012) |
| ACTC1 | Alpha-cardiac actin | -1.7 | (Tondeleir et al., 2011) | |
| ACTB | Beta-actin | -1.5 | (Guo et al., 2013) | |
| PLEC | Plectin | -1.2 | (Katada, K., et al., 2012) | |
| Epithelial-Mesenchymal Transition | YWHAE | 14-3-3ε | -10.0 | (Liu et al., 2013a) |
| PPP2CA | Serine/threonine-protein phosphatase 2A catlytic subunit alpha isolform | -3.3 | (Bhardwaj et al., 2014) | |
| VIM | Vimentin | -1.2 | (Mendez et al., 2010) | |
| Cellular metabolism | ECHS1 | Enoyl-CoA Hydratase 1 | -3.7 | (Carracedo et al., 2013) |
| SLC25A3 | Solute carrier damily 25 member 3 | -2.4 | (Palmieri, 2013) | |
| CS | Citrate synthase | -2.4 | (Gaude and Frezza, 2014) | |
| Cellular migration/motility | EFHD2 | Swiprosin-1 | -4.1 | (Huh et al., 2015) |
| PFN1 | Profilin-1 | -1.8 | (Ding et al., 2012) | |
| Drug resistance | GLO1 | Glyoxalase 1 | -3.1 | (Sakamoto et al., 2000) |
| TAGLN2 | Transgelin-2 | -3.0 | (Chen et al., 2014) | |
| Protein transport | SEC63 | Translocation protein SEC63 homolog | -3.4 | (Zimmermann et al., 2006) |
| Cell adhesion | RSU1 | Ras suppressor protein 1 | -2.8 | (Kim et al., 2015b) |
| Immune response | WARS | Tryptophan-tRNA ligase, | -2.8 | (Mellor and Munn, 1999) |
| Prognosticator of survival | ALB | Serum albumin | -1.8 | (Gupta and Lis, 2010) |
| Post-translational modifications | HIST1H4B | Histone H4 | -1.6 | (van der Meijden et al., 1998) |
Rsc: Protein abundance ratio (HEY Oct4A KD/HEY vector control).