Table 7. Up regulated proteins in HEY Oct4A KD tumor xenografts.
| Category | Gene Name | Protein Description | Rsc | *Reference |
|---|---|---|---|---|
| Cellular metabolism | GOT1 | Aspartate aminotransferase | 2.0 | (Lyssiotis et al., 2013) |
| PYGB | Phosphorylase (EC 2.4.1.1) | 1.5 | (Willmann et al., 2015) | |
| GOT2 | Glutamic-oxaloacetic transaminase 2 | 1.1 | (Lyssiotis et al., 2014) | |
| IDH2 | Isocitrate dehydrogenase | 2.5 | (Borodovsky et al., 2012) | |
| ATP5O | ATP synthase subunit O | 1.3 | (Antoniel et al., 2014) | |
| Cellular growth | EIF42A | Eukaryotic translation initiation factor 4A2 | 5.9 | (Modelska et al., 2015) |
| CKB | Creatine kinase B-type | 3.7 | (Li et al., 2013b) | |
| PCBP2 hCG_2017557 | Poly(RC) binding protein 2 | 1.3 | (Hu et al., 2014a) | |
| TOMM34 | Mitochondrial import receptor subunit TOM34 | 1.3 | (Shimokawa et al., 2006) | |
| Apoptosis | POTEF | POTE ankyrin domain family member F | 23.0 | (Liu et al., 2009 |
| HSPH1 | Heat shock protein 105 kDa | 1.5 | (Kennedy et al., 2014) | |
| HNRNPH3 | Heterogeneous nuclear ribonucleoprotein H3 | 1.4 | (Garneau et al., 2005) | |
| COMT | Catechol-O-methyltransferase | 1.1 | (Wu et al., 2015b) | |
| Tumour suppression | AMY2A | Alpha amylase | 7.3 | (Kang et al., 2010) |
| HBB | Mutant beta-globin | 1.9 | (Onda et al., 2005) | |
| KRBA2 | KRAB-A domain-containing protein | 1.7 | (Li et al., 2003) | |
| TPM1 | Tropomyosin-1 | 1.2 | (Bharadwaj and Prasad, 2002) | |
| Oxidative stress response | NUDT5 | ADP-sugar pyrophosphatase | 3.1 | (McLennan, 2006) |
| DNAJB11 | DnaJ homolog subfamily B member 11 | 1.3 | (Nakanishi et al., 2004) | |
| HBA1 | Alpha-globin | 1.2 | (Li et al., 2013c) | |
| KPNA3 | Karyopherin subunit alpha-3 | 1.0 | (Young et al., 2013) | |
| Cytoskeletal | NEB | Nebulin | 1.9 | (Pappas et al., 2011) |
| TPM2 | Tropomyosin-2 | 1.1 | (Assinder et al., 2010) | |
| Calcium homeostasis | ATP2A1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 5.6 | (Arbabian et al., 2011) |
| ATP2A2 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | 4.1 | (Arbabian et al., 2011) | |
| Prognosticator of survival | ALB | Serum albumin | 3.7 | (Gupta and Lis, 2010) |
| HP | Haptoglobin (Zonulin) | 3.0 | (Zhao et al., 2007)* | |
| Drug resistance | COL6A3 | Collagen alpha-3(VI) chain | 3.7 | (Chen et al., 2013b) |
| TPI1 | Triosephosphate isomerase 1 | 1.0 | (Wang et al., 2008)* | |
| Iron transport | TF | Transferrin | 3.7 | (Kovac et al., 2011) |
| Angiogenesis | FMOD | Fibromodulin | 3.7 | (Jian et al., 2013) |
| Cancer stem cells | ANPEP | Aminopeptidase N | 1.1 | (Kim et al., 2012a) |
| mRNA regulation | NHP2L1 | NHP2-like protein 1 | 2.1 | (Esteller, 2011) |
| Cellular adhesion | PRELP | Prolargin | 2.0 | (Bengtsson et al., 2002) |
| Protein synthesis | RPS17L | 40S ribosomal protein S17 | 1.7 | (Chen and Roufa, 1988) |
| Immune response | FLNC | Filamin-C | 1.3 | (Marti et al., 1997) |
| Cellular migration/motility | BGN | Biglycan | 1.2 | (Hu et al., 2014b) |
Rsc: Protein abundance ratio (HEY Oct4A KD2/HEY vector control).