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. 2017 Apr 15;9(4):142–152. doi: 10.4251/wjgo.v9.i4.142

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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.

Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

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The figure exhibits the most frequent methylated genes/loci involved in step-by-step adenoma-carcinoma process in the context of colorectal cancer development. SFRP1: Secreted frizzled-related protein 1; CRABP1: Cellular retinoic acid binding protein 2; RUNX3: Runt-related transcription factor 3; CDH13: Cadherin 13; SLC5A8: Sodium solute symporter family 5 member 8; MINT1: Methylated in tumor locus 1; WNT5A: Wingless-type MMTV integration site family, member 5A; p14: Tumor protein 14; HLTF: Helicase-like transcription factor; ITGA4: Integrin, alpha 4; ESR1: Estrogen receptor 1; CDKN2A/p16: Cyclin-dependent kinase inhibitor 2A; CDH1: E-cadherin; CXCL12: Chemokine (C-X-C) ligand 12; ID4: Inhibitor of DNA binding 4; IRF8: Interferon regulatory factor 8; TIMP3: Tissue inhibitor of metalloproteinase 3; MGMT: O-6-methylguanine-DNAmethyltransferase; hMLH1: MutL homolog 1.