Table 1. In vitro cell growth inhibitory effects of compounds 3e, 4a-j, 5a-f and CA-4 (1).
| Compd | IC50a (nM) |
||||||
|---|---|---|---|---|---|---|---|
| HeLa | A549 | HT-29 | MCF-7 | Jurkat | RS 4;11 | SEM | |
| 4a | 2.1 ± 0.5 | 12.6 ± 5.4 | 0.5 ± 0.1 | 1.1 ± 0.5 | 73.2 ± 5.2 | 14.3 ± 6.2 | 40.2 ± 11.0 |
| 4b | >10000 | >10000 | >10000 | >10000 | >10000 | >10000 | 9550 ± 2050 |
| 4c | 2818 ± 169 | 8785 ± 2309 | 1397 ± 384 | 2587 ± 447 | 5576 ± 888 | 840 ± 260 | 2211 ± 256 |
| 4d | 31.0 ± 16.0 | 92.3 ± 21.5 | 53.0 ± 24.6 | 243.8 ± 74.2 | 102.2 ± 22.6 | 25.3 ± 3.2 | 133.8 ± 39.5 |
| 4e | 10.8 ± 4.7 | 179.3 ± 36.3 | 40.8 ± 19.7 | 27.7 ± 12.0 | 18.7 ± 6.0 | 7.6 ± 2.3 | 35.6 ± 12.5 |
| 4f | > 10000 | > 10000 | > 10000 | > 10000 | 5233 ± 88.2 | 5333 ± 166.7 | 3633 ± 171 |
| 4g | 2.4 ± 0.6 | 0.65 ± 0.08 | 3.3 ± 1.1 | 2.5 ± 0.7 | 4.6 ± 1.0 | 0.35 ± 0.15 | 3.9 ± 0.8 |
| 4h | 168.8 ± 75.5 | 138.3 ± 13.7 | 207.0 ± 93.0 | 143.8 ± 64.3 | 512.2 ± 92.7 | 47.0 ± 13.9 | 233.3 ± 34.6 |
| 4i | 0.9 ± 0.3 | 0.5 ± 0.1 | 20.2 ± 8.8 | 4.5 ± 1.8 | 4.1 ± 1.1 | 2.1 ± 0.2 | 6.1 ± 2.3 |
| 4j | 4.2 ± 1.3 | 20.3 ± 11.4 | 0.9 ± 0.5 | 1.5 ± 0.6 | 77.7 ± 6.1 | 20.2 ± 5.4 | 51.0 ± 13.5 |
| 5a | 37.0 ± 14.4 | 45.2 ± 12.5 | 315.2 ± 145.3 | 5.2 ± 2.4 | 638.3 ± 153.5 | 249.5 ± 89.3 | 37.0 ± 14.4 |
| 5b | >10000 | >10000 | >10000 | >10000 | 9000 ± 577.4 | >10000 | >10000 |
| 5c | 2557 ± 474.6 | >10000 | >10000 | >10000 | 5250 ± .934 | 815 ± 405.9 | 6567 ± 499.6 |
| 5d | 148.2 ± 55.3 | 2579 ± 289 | 523.3 ± 61.8 | 360.0 ± 52.6 | 921.7 ± 76.6 | 635.2 ± 387.1 | 351.7 ± 77.8 |
| 5e | 24.0 ± 10.5 | 243.3 ± 51.5 | 12.3 ± 5.9 | 83.8 ± 20.2 | 43.6 ± 12.3 | 17.3 ± 4.2 | 96.6 ± 22.5 |
| 5f | 2.0 ± 0.8 | 1.5 ± 0.44 | 1.9 ± 0.8 | 0.4 ± 0.08 | 50.7 ± 10.8 | 11.9 ± 6.3 | 13.3 ± 4.2 |
| 3e | 1978 ± 779.7 | 2758 ± 1203 | 3700 ± 263 | 1933 ± 448 | 7200 ± 586 | 2972 ± 738.3 | 1978 ± 779.7 |
| CA-4 | 4 ± 0.1 | 180 ± 50 | 3100 ± 100 | 370 ± 100 | 5 ± 0.6 | 0.8 ± 0.2 | 5 ± 0.1 |
aIC50 = compound concentration required to inhibit tumor cell proliferation by 50%. Values are the mean ± SE from the dose-response curves of at least three independent experiments carried out in triplicate.