Table 3.
Correlations between adiponectin plasma levels, gene expression, DNA methylation, and offspring clinical variables in the cohort as a whole (O-GDM, O-T1DM, and O-BP combined)
| Adiponectin plasma levels | ADIPOQ gene expression | Average ADIPOQ DNA methylation | |
|---|---|---|---|
| Adiponectin plasma levels | 0.169 (0.032) | −0.084 (0.376) | |
| ADIPOQ gene expression | 0.169 (0.032) | −0.266 (0.013) | |
| Average ADIPOQ DNA methylation | −0.084 (0.376) | −0.266 (0.013) | |
| BMI (kg/m2) | −0.195 (0.005) | −0.417 (<0.001) | 0.359 (<0.001) a |
| Fasting insulin (pmol/l) | −0.281 (<0.001) | −0.341 (<0.001) | 0.318 (0.001) a |
| Fasting plasma glucose (mmol/l) | −0.145 (0.039) | −0.163 (0.039) | 0.195 (0.038) a |
| 120-min plasma glucose (mmol/l) | −0.141 (0.049) | −0.063 (0.441) | 0.219 (0.022) a |
| Total body fat (%) | −0.078 (0.268) | −0.164 (0.038) | 0.212 (0.024) a |
| HOMA-IR | −0.289 (<0.001) | −0.360 (<0.001) | 0.344(<0.001) a |
| Mean systolic blood pressure (mmHg) | −0.195 (0.005) | −0.274 (<0.001) | 0.175 (0.062)a |
| Mean diastolic blood pressure (mmHg) | −0.139 (0.048) | −0.351 (<0.001) | 0.148 (0.115)a |
| Waist circumference (cm) | −0.239 (0.001) | −0.439 (<0.001) | 0.447 (<0.001) a |
| HDL cholesterol (mmol/l) | 0.240 (0.001) | 0.356 (<0.001) | −0.286 (0.002) a |
Data is Spearman’s rank coefficient R (p value) unless otherwise indicated. p values <0.05 are in italics
O-GDM offspring of women with gestational diabetes, O-T1DM offspring of women with type 1 diabetes, O-BP offspring of women from the background population
aPearson’s correlation coefficient