Table 4.
Correlations between resistin plasma levels, gene expression, DNA methylation, and offspring clinical variables in the cohort as a whole (O-GDM, O-T1DM, and O-BP combined)
| Resistin plasma levels | RETN gene expression | Average RETN DNA methylation | |
|---|---|---|---|
| Resistin plasma levels | 0.070 (0.380) | −0.162 (0.061) | |
| RETN gene expression | 0.070 (0.380) | 0.109 (0.270) | |
| Average RETN DNA methylation | −0.162 (0.061) | 0.109 (0.270) | |
| BMI (kg/m2) | 0.177 (0.011) | −0.110 (0.165) | −0.270 (0.002) a |
| Fasting insulin (pmol/l) | 0.198 (0.007) | 0.003 (0.970) | −0.327 (<0.001) a |
| Fasting plasma glucose (mmol/l) | 0.154 (0.027) | −0.051 (0.523) | −0.183 (0.033) a |
| 120-min plasma glucose (mmol/l) | 0.022 (0.762) | 0.002 (0.977) | −0.089 (0.318)a |
| Total body fat (%) | 0.230 (0.001) | −0.044 (0.577) | −0.320 (<0.001) a |
| HOMA-IR | 0.224 (0.002) | −0.012 (0.883) | −0.344 (<0.001) a |
| Mean systolic blood pressure (mmHg) | 0.079 (0.262) | −0.116 (0.144) | −0.051 (0.555)a |
| Mean diastolic blood pressure (mmHg) | 0.212 (0.002) | −0.183 (0.021) | −0.233 (0.007) a |
| Waist circumference (cm) | 0.058 (0.409) | −0.131 (0.099) | −0.260 (0.002) a |
| HDL cholesterol (mmol/l) | −0.017 (0.813) | 0.016 (0.844) | 0.096 (0.268)a |
Data is Spearman’s rank coefficient R (p value) unless otherwise indicated. p values <0.05 are in italics
O-GDM offspring of women with gestational diabetes, O-T1DM offspring of women with type 1 diabetes, O-BP offspring of women from the background population
aPearson’s correlation coefficient