Table 4.
Study characteristics Author and year, number of patients allocated to control or intervention group and the type of patients and/or procedures performed during the study
| Reference (Author and year) | Control/intervention (n) | Type of patients/procedures |
|---|---|---|
| Shore-Lesserson 1999 [33] | 52/53 | Cardiac surgery Moderate to high risk of microvascular bleeding (single/multiple valve replacement, combined CAB + valvular procedure, cardiac reoperation, thoracic aortic replacement). CPB performed with moderate hypothermia. |
| Nuttall 2001 [31] | 51/41 | Cardiac surgery All types of elective cardiac surgery developing abnormal bleeding after CPB. |
| Royston 2001 [32] | 30/30 | Cardiac surgery 10% in each group had heart transplantation, 50% in each group had revascularization (multiple grafts with an estimated CPB-time >100 min), 40% in each group Ross procedure, multiple valve or valve and revascularization surgery. |
| Avidan 2004 [29] | 51/51 | Cardiac surgery Routine elective first time coronary artery surgery with CPB. Cooled to 32 °C. |
| Ak 2009 [28] | 110/114 | Cardiac surgery Elective first time coronary artery bypass graft (CABG) with CPB. |
| Westbrook 2009 [35] | 37/32 | Cardiac surgery Presenting for cardiac surgery except lung transplantations. |
| Girdauskas 2010 [30] | 29/27 | Aortic surgery Patients undergoing aortic surgery with hypothermic circulatory arrest. 25 patients with acute type A dissection. |
| Wang 2010 [37] | 14/14 | Orthotopic liver transplantation |
| Paniagua 2011 [36] | 9/13 | Cardiac surgery Patients scheduled for cardiac surgery with extracorporeal circulation with major post-operative bleeding (>300 mL). |
| Schaden 2012 [38] | 16/14 | Surgical excision of burn wounds Surgical intervention performed on 3rd day after trauma. |
| Weber 2012 [34] | 50/50 | Cardiac surgery Patients scheduled for elective, complex cardiothoracic surgery (combined coronary artery bypass, graft and valve surgery, double/triple valve procedures, aortic surgery or redo surgery) with CPB. |
| Barinov 2015 [41] | 29/90 | Postpartum obstetric haemorrhage |
| Gonzalez 2015 [22] | 55/56 | Trauma patients Meeting criteria for massive transfusion protocol (MTP) activation on arrival to ED: systolic blood pressure <70 mmHg or SBP 70 – 90 mmHg with heart rate 108 beats/min, in addition to any of the following injury patterns: penetrating torso wound, unstable pelvic fracture, or abdominal ultrasound suspicious of bleeding in more than one region. |
| De Pietri 2015 [39] | 30/30 | Hepatic surgery Patients with cirrhosis + significant coagulopathy (defined as INR >1,8 and/or platelet count <50 × 109/L) undergoing invasive procedure. |
| Cao 2016 [40] | 28/32 | Scoliosis surgery Patients with an expected surgical bleeding > 1000 ml and the American Society of Anesthesiologists rating I-II in addition to a body mass index (BMI) 18 to 24 kg/m2 |
CAB coronary arterial bypass, CABG coronary artery bypass graft, CPB cardio pulmonary bypass, MTP massive transfusion protocol, ED emergency department, SBP systolic blood pressure, INR international normalised ratio