Table 2.
H. pylori infection, status of cagA/babA2 and vacA genotypes in patients with gastric pathology
| Diagnosis | p value | |||
|---|---|---|---|---|
| CG n (%) | GU n (%) | GC n (%) | ||
| H. pylori | ||||
| Negative | 400 (52.2) | 58 (50.4) | 15 (38.5) | 0.243Ф |
| Positive | 367 (47.8) | 57 (49.6) | 24 (61.5) | |
| Total | 767 (100) | 115 (100) | 39 (100) | |
| Distribution of H. pylori by age group | ||||
| ≤20 years old | 16 (4.4) | 1 (1.8) | 0 | 0.003δ |
| 20–39 years old | 120 (32.7) | 10 (17.5) | 4 (16.7) | |
| 40–59 years old | 162 (44.1) | 26 (45.6) | 8 (33.3) | |
| ≥60 years old | 69 (18.8) | 20 (35.1) | 12 (50) | |
| Total | 367 (100) | 57(100) | 24 (100) | |
| vacA alleles | ||||
| s1 | 290 (83.3) | 49 (84.5) | 21(91.3) | |
| s2 | 58 (16.7) | 9 (15.5) | 2 (8.7) | |
| m1 | 201 (60.9) | 36 (67.9) | 20 (90.9) | |
| m2 | 129 (39.1) | 17 (32.1) | 2 (9.1) | |
| vacA genotypes | ||||
| s1m1 | 166 (45.2) | 35 (61.4) | 20 (83.3) | 0.017δ |
| s1m2 | 62 (16.8) | 7 (12.2) | 0 | |
| s2m1 | 9 (2.5) | 0 | 0 | |
| s2m2 | 41 (11.2) | 9 (15.8) | 2 (8.3) | |
| s1m1/s1m2 | 22 (6) | 1 (1.8) | 0 | |
| s2m1/s2m2 | 4 (1.1) | 0 | 0 | |
| s1m0 | 18 (4.9) | 5 (8.8) | 1 (4.2) | |
| s0m2 | 4 (1.1) | 0 | 0 | |
| Non-typeable | 41 (11.2) | 0 | 1 (4.2) | |
| Total | 367 (100) | 57 (100) | 24 (100) | |
| cagA | ||||
| Negative | 158 (43.0) | 22 (38.6) | 10 (41.7) | 0.925Ф |
| Positive | 209 (57.0) | 35 (61.4) | 14 (58.3) | |
| Total | 367 (100) | 57 (100) | 24 (100) | |
| babA2 | ||||
| Negative | 268 (73.0) | 42 (73.7) | 14 (58.3) | 0.114Ф |
| Positive | 99 (27.0) | 15 (26.3) | 10 (41.7) | |
| Total | 367 (100) | 57 (100) | 24 (100) | |
| vacA/cagA genotypes a | ||||
| s2m2/cagA− | 26 (14.1) | 3 (7.9) | 1 (6.3) | 0.114δ |
| s2m2/cagA+ | 7 (3.8) | 2 (5.3) | 0 | |
| s1m1/cagA− | 21 (11.4) | 11 (28.9) | 2 (12.5) | |
| s1m1/cagA+ | 130 (70.7) | 22 (57.9) | 13 (81.3) | |
| Total | 184 (100) | 38 (100) | 16 (100) | |
CG chronic gastritis, GU gastric ulcer, GC gastric cancer
Ф X2 test, δ Exact Fisher test; s0: non-typeable for signal region. m0: non-typeable for middle region
aIn this analysis only were included the infections caused by one vacA genotype